Brain γ-aminobutyric acid (GABA) detectionin vivowith theJ-editing1H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability

Volume: 29, Issue: 7, Pages: 932 - 942
Published: May 13, 2016
Abstract
Abnormalities in brain γ-aminobutyric acid (GABA) have been implicated in various neuropsychiatric and neurological disorders. However, in vivo GABA detection by (1) H MRS presents significant challenges arising from the low brain concentration, overlap by much stronger resonances and contamination by mobile macromolecule (MM) signals. This study addresses these impediments to reliable brain GABA detection with the J-editing difference technique...
Paper Details
Title
Brain γ-aminobutyric acid (GABA) detectionin vivowith theJ-editing1H MRS technique: a comprehensive methodological evaluation of sensitivity enhancement, macromolecule contamination and test-retest reliability
Published Date
May 13, 2016
Volume
29
Issue
7
Pages
932 - 942
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