C-Jun N-terminal kinase pathway and neurodegenerative disease

c-Jun N-terminal kinases(JNKs)play an integral role in neuronal death in multiple cell lines following a wide variety of stimuli and in a number of physiological functions which have been recognized as important enzymes in cellular function.JNK has been implicated in several neurodegenerative diseases.Data are emerging to extend the understanding of the JNK signaling and confirm the possibility that targeting JNK signaling may offer an effective...