Analysis of HBV drug-resistant mutation in 1121 patients with chronic hepatitis B
Abstract
Objective To analyze hepatitis B virus(HBV) mutation associated with nucleos(t)ide analogue resistance in multiple sites in the reverse transcriptase(RT) gene in a large sample of patients with chronic hepatitis B.Methods Serum HBV DNA was extracted individually from 1 121 patients.A nested PCR assay with high sensitivity and specificity developed by our laboratory was employed for the RT gene amplification.Direct sequencing of PCR product was...
Paper Details
Title
Analysis of HBV drug-resistant mutation in 1121 patients with chronic hepatitis B
Published Date
Jan 1, 2009
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