AID is required for germinal center–derived lymphomagenesis
Abstract
Most human B cell non-Hodgkin's lymphomas (B-NHLs) derive from germinal centers (GCs), the structure in which B cells undergo somatic hypermutation (SHM) and class switch recombination (CSR) before being selected for high-affinity antibody production. The pathogenesis of B-NHL is associated with distinct genetic lesions, including chromosomal translocations and aberrant SHM, which arise from mistakes occurring during CSR and SHM. A direct link...
Paper Details
Title
AID is required for germinal center–derived lymphomagenesis
Published Date
Dec 9, 2007
Journal
Volume
40
Issue
1
Pages
108 - 112
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