37 AN ACUTE LUNG INJURY-ASSOCIATED CORTACTIN POLYMORPHISM ALTERS PULMONARY ENDOTHELIAL CELL BARRIER FUNCTION.

Introduction

Acute lung injury (ALI) syndromes are highly morbid consequences of systemic inflammatory conditions such as sepsis. Inflammation-induced disruption during ALI of the endothelial cell (EC) barrier that lines the pulmonary vasculature results in leakage of fluid, protein, and cells into the airspaces of the lung, resulting in respiratory failure. We have previously described (Dudek et al. J Biol Chem 2004;279:24692-700) a...