TNFα expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis

Introduction: Tumor necrosis factor (TNFα) has been invoked as an adipostat. Accordingly, the adipose tissue expression of TNFα has been shown to be proportional to the degree of adiposity. The regulatory role of TNFα in obesity may be controlled by several mechanisms. These include the inhibitory effect on LPL activity, the mediation on glucose homeostasis or the effect on leptin. To assess the role of TNFα in obesity we measured adipocyte TNFα...