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Cancer metabolism : a therapeutic perspective

Published on Jan 1, 2017in Nature Reviews Clinical Oncology34.11
· DOI :10.1038/nrclinonc.2016.60
Ubaldo E. Martinez-Outschoorn50
Estimated H-index: 50
(Thomas Jefferson University),
Maria Peiris-Pagès13
Estimated H-index: 13
+ 2 AuthorsMichael P. Lisanti130
Estimated H-index: 130
Abstract
Metabolic reprogramming to support tumour growth is a near universal characteristic of cancer, and thus targeting cancer metabolism has been, and continues to be, a focus for drug-development efforts. In this Review, the authors describe the various metabolic alterations and vulnerabilities of tumours that are potentially important targets for anticancer agents, highlighting both the challenges and opportunities.
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  • Citations (294)
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