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Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults.

Published on Apr 1, 2016in Nutrition & Diabetes3.098
· DOI :10.1038/nutd.2016.8
Elizabeth Chmelo9
Estimated H-index: 9
(Wake Forest University),
D. P. Beavers3
Estimated H-index: 3
(Wake Forest University)
+ 3 AuthorsKristen M. Beavers16
Estimated H-index: 16
(Wake Forest University)
Abstract
Legacy effects of short-term intentional weight loss on total body and thigh composition in overweight and obese older adults
  • References (25)
  • Citations (5)
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References25
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#1Barbara J. Nicklas (Wake Forest University)H-Index: 62
#2Elizabeth Chmelo (Wake Forest University)H-Index: 9
Last. Anthony P. Marsh (Wake Forest University)H-Index: 21
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Background: Resistance training (RT) improves muscle strength and overall physical function in older adults. RT may be particularly important in the obese elderly who have compromised muscle function. Whether caloric restriction (CR) acts synergistically with RT to enhance function is unknown. Objective: As the primary goal of the Improving Muscle for Functional Independence Trial (I’M FIT), we determined the effects of adding CR for weight loss on muscle and physical function responses to RT in...
52 CitationsSource
#1Henry J. Pownall (BCM: Baylor College of Medicine)H-Index: 54
#2George A. Bray (Pennington Biomedical Research Center)H-Index: 117
Last. Karen C. Johnson (UTHSC: University of Tennessee Health Science Center)H-Index: 71
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Objective To determine the effects of an intensive lifestyle intervention vs. a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years.
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Purpose of reviewThe impact of weight cycling on body composition and metabolic risk remains controversial. Very few studies, however, meet the methodological requirements to analyze and normalize changes in body composition with weight loss and regain.Recent findingsMethodological drawbacks that li
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#1Robyn A. Tamboli (Vandy: Vanderbilt University)H-Index: 12
#2Igal Breitman (Vandy: Vanderbilt University)H-Index: 5
Last. Naji N. Abumrad (Vandy: Vanderbilt University)H-Index: 50
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Objectives We sought to determine: (1) if early weight regain between 1 and 2 years after Roux-en-Y gastric bypass (RYGB) is associated with worsened hepatic and peripheral insulin sensitivity, and (2) if preoperative levels of ghrelin and leptin are associated with early weight regain after RYGB. Methods Hepatic and peripheral insulin sensitivity and ghrelin and leptin plasma levels were assessed longitudinally in 45 subjects before RYGB and at 1 month, 6 months, 1 year, and 2 years postoperati...
17 CitationsSource
#1Mauro Zamboni (University of Verona)H-Index: 49
#2A Rossi (University of Verona)H-Index: 43
Last. Gloria Mazzali (University of Verona)H-Index: 20
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Abstract Age related increase in body fat mass, visceral adipose tissue (AT), and ectopic fat deposition are strongly related to worse health conditions in the elderly. Moreover, with aging higher inflammation in adipose tissue may be observed and may contribute to inflammaging. Aging may significantly affect AT function by modifying the profile of adipokines produced by adipose cells, reducing preadipocytes number and their function and increasing AT macrophages infiltration. The initiating eve...
32 CitationsSource
#1Kristen M. Beavers (Wake Forest University)H-Index: 16
#2Daniel P. Beavers (Wake Forest University)H-Index: 22
Last. W. Jack Rejeski (Wake Forest University)H-Index: 58
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Objective Our primary objective was to determine the long-term effects of physical activity (PA) and weight loss (WL) on body composition in overweight/obese older adults. Secondarily, the association between change in body mass and composition on change in several cardiometabolic risk factors and mobility was evaluated. Design and Methods 288 older (X ± SD: 67.0 ± 4.8 years), overweight/obese (BMI 32.8 ± 3.8 kg/m2) men and women participated in this 18-month randomized, controlled trial. Treatm...
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OVERWEIGHT and obesity are significant public health problems, with recent estimates suggesting that 72.3% and 64.1% of adult men and women, respectively, have a body mass index (BMI) greater than or equal to 25kg/m2 (1). In women, postmenopausal status is associated with higher prevalence of overweight and obesity (2). Excessive body weight often predisposes to chronic disease, and accordingly, overweight and obese postmenopausal women are at increased risk of developing several cardiometabolic...
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#1Kristen M. Beavers (Wake Forest University)H-Index: 16
#2Daniel P. Beavers (Wake Forest University)H-Index: 22
Last. Stephen B. Kritchevsky (Wake Forest University)H-Index: 99
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Background: In older adults, every 0.1-m/s slower gait speed is associated with a 12% higher mortality. However, little research has identified risk factors for gait-speed decline. Objective: We assessed the association between several measures of body composition and age-related decline in gait speed. Design: Data were from 2306 older adults who were participating in the Health, Aging, and Body Composition cohort and were followed for 4 y (50% women; 38% black). Usual walking speed (m/s) over 2...
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#1Debra L. Waters (University of Otago)H-Index: 26
#2R. VawterH-Index: 1
Last. Dennis T. VillarealH-Index: 46
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Objectives To determine if long-term weight loss with associated improvement in physical and metabolic health can be maintained after lifestyle intervention in frail, obese older adults.
24 CitationsSource
#1Karen L. Villalon (University of Colorado Denver)H-Index: 3
#2Wendolyn S. Gozansky (University of Colorado Denver)H-Index: 18
Last. Wendy M. Kohrt (University of Colorado Denver)H-Index: 61
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Previously, we reported significant bone mineral density (BMD) loss in postmenopausal women after modest weight loss. It remains unclear whether the magnitude of BMD change in response to weight loss is appropriate (i.e., proportional to weight loss) and whether BMD is recovered with weight regain. We now report changes in BMD after a 1-year follow-up. Subjects (n = 23) in this secondary analysis were postmenopausal women randomized to placebo as part of a larger trial. They completed a 6-month ...
37 CitationsSource
Cited By5
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#1A Rossi (University of Verona)H-Index: 43
#2Sofia Rubele (University of Verona)H-Index: 3
Last. Mauro Zamboni (University of Verona)H-Index: 49
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#1Cilla Haywood (University of Melbourne)H-Index: 5
#2Priya Sumithran (University of Melbourne)H-Index: 8
The study aims to systematically review the available evidence regarding weight loss interventions (lifestyle, surgical, and pharmacological) for obesity in adults aged over 60 years. A search of prospective, randomized studies took place in January 2018, on Medline (Web of Science) and PubMed databases. Search terms included the following: elderly, obese, hypocaloric, pharmacotherapy, and bariatric surgery. Abstracts were screened for eligibility. A total of 256 publications regarding lifestyle...
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#1Denise K. Houston (Wake Forest University)H-Index: 45
#2Michael I. Miller (Wake Forest University)H-Index: 98
Last. Barbara J. Nicklas (Wake Forest University)H-Index: 62
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AbstractRandomized, controlled trials (RCTs) show intentional weight loss improves body composition and physical function in older adults; however, the long-term benefits (and risks) are unknown. W...
2 CitationsSource
It remains unclear as to what extent resistance training (RT) can attenuate muscle loss during caloric restriction (CR) interventions in humans. The objective here is to address if RT could attenuate muscle loss induced by CR in obese elderly individuals, through summarized effects of previous studies. Databases MEDLINE, Embase and Web of Science were used to perform a systematic search between July and August 2017. Were included in the review randomized clinical trials (RCT) comparing the effec...
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