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IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

Published on Jun 1, 2016in Nature Immunology23.53
· DOI :10.1038/ni.3447
Yoichiro Ohne2
Estimated H-index: 2
(MedImmune),
Jonathan S. Silver16
Estimated H-index: 16
(MedImmune)
+ 6 AuthorsYong-Jun Liu15
Estimated H-index: 15
(MedImmune)
Cite
Abstract
Cytokines of the IL-1 family have a range of effects on innate lymphoid cells. Liu and colleagues find that IL-1 facilitates the maturation and plasticity of group 2 innate lymphoid cells.
  • References (56)
  • Citations (109)
Cite
References56
Newest
Published on Jun 1, 2016in Nature Immunology23.53
Jonathan S. Silver16
Estimated H-index: 16
(MedImmune),
Jennifer Kearley4
Estimated H-index: 4
(MedImmune)
+ 10 AuthorsRussell P. Bowler42
Estimated H-index: 42
Group 1 and 3 innate lymphoid cells can be functionally plastic. Humbles and colleagues find that group 2 innate lymphoid cells in the lungs also exhibit phenotypic plasticity after exposure to infectious or noxious agents.
Published on Jun 1, 2016in Nature Immunology23.53
Suzanne M. Bal20
Estimated H-index: 20
(AMC: Academic Medical Center),
Jochem H Bernink1
Estimated H-index: 1
(AMC: Academic Medical Center)
+ 14 AuthorsPleun Hombrink13
Estimated H-index: 13
Transdifferentiation between group 1 and group 3 innate lymphoid cells (ILCs) has been observed in the gut. Spits and colleagues now show lung ILC2s are able to convert into ILC1s in an IL-12-dependent manner.
Published on Apr 1, 2016in Nature Immunology23.53
Åsa K. Björklund16
Estimated H-index: 16
,
Marianne Forkel6
Estimated H-index: 6
+ 5 AuthorsJenny Mjösberg24
Estimated H-index: 24
Innate lymphoid cells (ILCs) are increasingly appreciated as important participants in homeostasis and inflammation. Substantial plasticity and heterogeneity among ILC populations have been reported. Here we have delineated the heterogeneity of human ILCs through single-cell RNA sequencing of several hundreds of individual tonsil CD127(+) ILCs and natural killer (NK) cells. Unbiased transcriptional clustering revealed four distinct populations, corresponding to ILC1 cells, ILC2 cells, ILC3 cells...
Published on Aug 1, 2015in Immunity21.52
Danielle Califano8
Estimated H-index: 8
(Albany Medical College),
Jonathan J. Cho4
Estimated H-index: 4
(UF: University of Florida)
+ 5 AuthorsDorina Avram6
Estimated H-index: 6
(UF: University of Florida)
Summary Type 2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Here, we report that Bcl11b, previously considered a T-cell-specific transcription factor, acted directly upstream of the key ILC2 transcription factor Gfi1 to maintain its expression in mature ILC2s. Consequently, Bcl11b −/− ILC2s downregulated Gata3 and downstream genes, including Il1rl1 (encoding IL-33 receptor), and upregulated Rorc and type 3 ILC (ILC3) genes. Additionally, independent ...
Published on Jul 1, 2015in Immunity21.52
Jochem H. Bernink11
Estimated H-index: 11
(UvA: University of Amsterdam),
Lisette Krabbendam3
Estimated H-index: 3
(UvA: University of Amsterdam)
+ 11 AuthorsChristianne J. Buskens21
Estimated H-index: 21
(UvA: University of Amsterdam)
Summary Human group 1 ILCs consist of at least three phenotypically distinct subsets, including NK cells, CD127 + ILC1, and intraepithelial CD103 + ILC1. In inflamed intestinal tissues from Crohn's disease patients, numbers of CD127 + ILC1 increased at the cost of ILC3. Here we found that differentiation of ILC3 to CD127 + ILC1 is reversible in vitro and in vivo. CD127 + ILC1 differentiated to ILC3 in the presence of interleukin-2 (IL-2), IL-23, and IL-1β dependent on the transcription factor RO...
Published on Jul 1, 2015in Nature Medicine30.64
Gregory F. Sonnenberg27
Estimated H-index: 27
,
David Artis78
Estimated H-index: 78
Inflammation is defined as heat, redness, pain, swelling and loss of function. While acute inflammation is a necessary process to protect against infection and promote tissue repair, chronic inflammation directly contributes to the pathogenesis and progression of multiple infectious, inflammatory and metabolic disorders, including HIV/AIDS, inflammatory bowel disease, arthritis, psoriasis, allergy, asthma, diabetes, obesity and cancer1,2. While there are many well characterized cellular and mole...
Published on Jun 1, 2015in Journal of Experimental Medicine10.89
Jennifer A. Walker15
Estimated H-index: 15
(Medical Research Council),
Christopher J. Oliphant3
Estimated H-index: 3
(Medical Research Council)
+ 7 AuthorsAndrew Neil James Mckenzie13
Estimated H-index: 13
(Medical Research Council)
Group 2 innate lymphoid cells (ILC2s) are often found associated with mucosal surfaces where they contribute to protective immunity, inappropriate allergic responses, and tissue repair. Although we know they develop from a common lymphoid progenitor in the bone marrow (BM), the specific lineage path and transcriptional regulators that are involved are only starting to emerge. After ILC2 gene expression analysis we investigated the role of Bcl11b, a factor previously linked to T cell commitment, ...
Published on Jun 1, 2015in Journal of Experimental Medicine10.89
Yong Yu7
Estimated H-index: 7
(Wellcome Trust Sanger Institute),
Cui Wang4
Estimated H-index: 4
(Wellcome Trust Sanger Institute)
+ 10 AuthorsNancy A. Jenkins153
Estimated H-index: 153
(Houston Methodist Hospital)
Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 de...
Published on Mar 1, 2015in Nature43.07
Jonathan R. Brestoff14
Estimated H-index: 14
,
Brian S. Kim23
Estimated H-index: 23
+ 8 AuthorsPatrick Seale42
Estimated H-index: 42
Group 2 innate lymphoid cells are shown to have a critical role in energy homeostasis by producing methionine-enkephalin peptides in response to interleukin 33, thus promoting the beiging of white adipose tissue; increased numbers of beige (also known as brown-like or brite) fat cells in white adipose tissue leads to increased energy expenditure and decreased adiposity.
Published on Mar 1, 2015in Immunity21.52
Jennifer Kearley4
Estimated H-index: 4
(MedImmune),
Jonathan S. Silver16
Estimated H-index: 16
(MedImmune)
+ 12 AuthorsGj. Criner45
Estimated H-index: 45
(TU: Temple University)
Summary Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease and is presumed to be central to the altered responsiveness to recurrent infection in these patients. We examined the effects of smoke priming underlying the exacerbated response to viral infection in mice. Lack of interleukin-33 (IL-33) signaling conferred complete protection during exacerbation and prevented enhanced inflammation and exaggerated weight loss. Mechanistically, smoke was required to upregul...
Cited By109
Newest
Published on May 14, 2019in Nature Communications11.88
Korneliusz Golebski6
Estimated H-index: 6
(UvA: University of Amsterdam),
Xavier Romero Ros4
Estimated H-index: 4
(UvA: University of Amsterdam)
+ 11 AuthorsSven Seys15
Estimated H-index: 15
(Katholieke Universiteit Leuven)
Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing and remodeling, features that are dysfunctional in patients with cystic fibrosis (CF). The mechanisms by which ILCs contribute to CF-immunopathology are ill-defined. Here, we show that group 2 ILCs (ILC2s) transdifferentiated into IL-17-secreting cells in the presence of the epithelial-derived cytokines IL-1β, IL-23 and TGF-β. This...
Published on Dec 1, 2019in Current Opinion in Microbiology6.92
Dario S. Zamboni31
Estimated H-index: 31
(USP: University of São Paulo),
David L. Sacks77
Estimated H-index: 77
(NIH: National Institutes of Health)
The inflammasomes are multi-molecular platforms that are activated in host cell cytoplasm when the innate immune cells are infected with pathogens or exposed to damage signals. Many independent groups reported that Leishmania infection trigger activation of the NLRP3 inflammasome in macrophages for restriction of intracellular parasite replication. Accordingly, Leishmania can dampen NLRP3 activation as an evasion strategy. In vivo , the NLRP3 inflammasome can promote parasite clearance, but the ...
Published on Dec 1, 2019in Nature Communications11.88
Alyse L. Frisbee1
Estimated H-index: 1
(University of Virginia Health System),
Mahmoud Saleh3
Estimated H-index: 3
(University of Virginia Health System)
+ 10 AuthorsStephen D. Turner21
Estimated H-index: 21
(UVA: University of Virginia)
Clostridium difficile (C. difficile) incidence has tripled over the past 15 years and is attributed to the emergence of hypervirulent strains. While it is clear that C. difficile toxins cause damaging colonic inflammation, the immune mechanisms protecting from tissue damage require further investigation. Through a transcriptome analysis, we identify IL-33 as an immune target upregulated in response to hypervirulent C. difficile. We demonstrate that IL-33 prevents C. difficile-associated mortalit...
Published on 2019in Frontiers in Immunology4.72
Gavin Lewis3
Estimated H-index: 3
(Janssen Pharmaceutica),
Bowen Wang2
Estimated H-index: 2
(SC: University of Southern California)
+ 7 AuthorsRichard Lo1
Estimated H-index: 1
(SC: University of Southern California)
Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation. However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short chain fatty acids (SCFAs), such as butyrate, derived from fermentation of dietary fibers by the gut microbiota inhibit pulmonary ILC2 functions and subsequent development of airway hyperreactivity (AHR). We further show that SCFAs modulate GATA3, oxidative phosphorylation and glycolytic metabolic pathways in pulmonary IL...
Published on Sep 1, 2019in Trends in Immunology13.00
Luke Riggan (UCLA: University of California, Los Angeles), Aharon G. Freud22
Estimated H-index: 22
(OSU: Ohio State University),
Timothy E. O’Sullivan (UCLA: University of California, Los Angeles)
Innate lymphoid cells (ILCs) consist of a heterogeneous family of lymphocytes that regulate tissue homeostasis and can contribute to pathology in mice and humans. Mammalian group 1 ILCs are defined by the production of interferon (IFN)-γ and the functional dependence on the transcription factor T-bet. While recent studies demonstrate that group 1 ILCs consist of circulating mature natural killer (NK) cells and tissue-resident ILC1s, the functional, phenotypic, and developmental properties that d...
Published on 2019in Frontiers in Immunology4.72
Tim Willinger14
Estimated H-index: 14
(KI: Karolinska Institutet)
Innate lymphoid cells (ILCs) are specialized immune cells that rapidly respond to environmental challenges, such as infection and tissue damage. ILCs play an important role in organ homeostasis, tissue repair, and host defense in the mucosal tissues intestine and lung. ILCs are sentinels of healthy tissue function, yet it is poorly understood how ILCs are recruited, strategically positioned, and maintained within tissues. Accordingly, ILC migration is an area that has recently come into focus an...
Published on 2019in European Journal of Immunology4.70
Tzu‐Yi Chan (NCKU: National Cheng Kung University), Chia-Liang Yen1
Estimated H-index: 1
(NCKU: National Cheng Kung University)
+ 6 AuthorsChi-Chang Shieh18
Estimated H-index: 18
(NCKU: National Cheng Kung University)
Published on Jul 1, 2019
Zheyi Li1
Estimated H-index: 1
(ANU: Australian National University),
R.J. Jackson (ANU: Australian National University), C. Ranasinghe (ANU: Australian National University)
Abstract This study demonstrates that modulation of IL-25 and IL-33 cytokines responsible for innate lymphoid cell 2 (ILC2) activation/function can differentially regulate ILC profiles at the vaccination site, in a vaccine route-dependent manner. Specifically, recombinant fowlpox (rFPV) vector-based vaccine co-expressing an adjuvant that transiently sequestered IL-25 (FPV-HIV-IL-25 binding protein), delivered intramuscularly (i.m.) was able to induce significantly lower IL-25R + ILC2-deived IL-1...
Published on Jul 1, 2019in Nature Immunology23.53
Jochem H. Bernink11
Estimated H-index: 11
(UvA: University of Amsterdam),
Yoichiro Ohne2
Estimated H-index: 2
(MedImmune)
+ 13 AuthorsSophie van Tol (UvA: University of Amsterdam)
Here we identify a group 2 innate lymphoid cell (ILC2) subpopulation that can convert into interleukin-17 (IL-17)-producing NKp44− ILC3-like cells. c-Kit and CCR6 define this ILC2 subpopulation that exhibits ILC3 features, including RORγt, enabling the conversion into IL-17-producing cells in response to IL-1β and IL-23. We also report a role for transforming growth factor-β in promoting the conversion of c-Kit− ILC2s into RORγt-expressing cells by inducing the upregulation of IL23R, CCR6 and KI...