IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
Abstract
Group 2 innate lymphoid cells (ILC2 cells) are important for type 2 immune responses and are activated by the epithelial cytokines interleukin 33 (IL-33), IL-25 and thymic stromal lymphopoietin (TSLP). Here we demonstrated that IL-1β was a critical activator of ILC2 cells, inducing proliferation and cytokine production and regulating the expression of epithelial cytokine receptors. IL-1β also governed ILC2 plasticity by inducing low expression...
Paper Details
Title
IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
Published Date
Jun 1, 2016
Journal
Volume
17
Issue
6
Pages
646 - 655
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