Eukaryotic DNA Polymerases in Homologous Recombination
Abstract
Homologous recombination (HR) is a central process to ensure genomic stability in somatic cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity of the process. A number of recent studies have demonstrated that DNA synthesis during HR is conservative, less processive, and more mutagenic than replicative DNA synthesis. In this review, we describe mechanistic features of DNA synthesis during different types of...
Paper Details
Title
Eukaryotic DNA Polymerases in Homologous Recombination
Published Date
Nov 23, 2016
Journal
Volume
50
Issue
1
Pages
393 - 421
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