Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1
Abstract
Thrombin and membrane lipid peroxidation (MLP) have been implicated in various central nervous system (CNS) disorders from CNS trauma to stroke, Alzheimer's (AD) and Parkinson's (PD) diseases. Because thrombin also induces MLP in platelets and its involvement in neurodegenerative diseases we hypothesized that its deleterious effects might, in part, involve formation of MLP in neuronal cells. We previously showed that thrombin induced caspase-3...
Paper Details
Title
Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1
Published Date
Jul 1, 2016
Journal
Volume
1643
Pages
10 - 17
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