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Influence of cytotoxic butyltin complexes with 2-sulfobenzoic acid on the thermotropic phase behavior of lipid model membranes

Published on Jan 1, 2017in Journal of Thermal Analysis and Calorimetry2.47
· DOI :10.1007/s10973-016-5489-4
Hanna Pruchnik10
Estimated H-index: 10
(Wroclaw University of Environmental and Life Sciences)
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Abstract
In the previous study, we showed that butyltin complexes with 2-sulfobenzoic acid (commonly referred to as BTsbz) exhibit a very wide biological activity. The BTsbz in vitro are very active cytotoxic agents against tumor cells—more effective than cisplatin and carboplatin (traditional anticancer drugs). These complexes are antibacterial agents against gram-positive and gram-negative bacteria, as well. The aim of the present study was to investigate the influence of BTsbz on the thermotropic phase behavior of dipalmitoylphosphatidylcholine (DPPC) model membranes. The effect of this compound on the multilamellar liposomes was studied mainly by the means of differential scanning calorimetry and additionally by the steady-state fluorimetry and infrared spectroscopy. All investigated butyltin complexes with 2-sulfobenzoic acid change the thermotropic properties of lipid model membranes: The temperature of the main phase transition of DPPC is slightly decreased, and the transition’s cooperativity of the peak is very much reduced. With increasing concentration, all investigated compounds abolished the pretransition. The results suggest that BTsbz are very active in the hydrophilic area of DPPC bilayer and at the same time have an effect on membrane fluidity.
  • References (30)
  • Citations (4)
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References30
Newest
#1Aleksandra Włoch (Wroclaw University of Environmental and Life Sciences)H-Index: 5
#2Paulina Strugała (Wroclaw University of Environmental and Life Sciences)H-Index: 6
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 6 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 32
view all 7 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Aleksandra Włoch (Wroclaw University of Environmental and Life Sciences)H-Index: 5
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 5 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 32
view all 3 authors...
#1Seyedeh Hoda Alavizadeh (MUMS: Mashhad University of Medical Sciences)H-Index: 7
#2Ali Badiee (MUMS: Mashhad University of Medical Sciences)H-Index: 16
Last.Mahmoud Reza Jaafari (MUMS: Mashhad University of Medical Sciences)H-Index: 31
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#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Małgorzata Latocha (Medical University of Silesia)H-Index: 12
Last.Florian P. Pruchnik (UWr: University of Wrocław)H-Index: 18
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Cited By4
Newest
#1Elizabeth Uria-Canseco (UNAM: National Autonomous University of Mexico)
#2Silvia Pérez-Casas (UNAM: National Autonomous University of Mexico)H-Index: 13
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Dorota Bonarska-Kujawa (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Halina Kleszczyńska (Wroclaw University of Environmental and Life Sciences)H-Index: 15
view all 5 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 32
view all 3 authors...
#1Hanna Pruchnik (Wroclaw University of Environmental and Life Sciences)H-Index: 10
#2Teresa Kral (Wroclaw University of Environmental and Life Sciences)H-Index: 9
Last.Martin HofH-Index: 32
view all 3 authors...
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