A role for human homologous recombination factors in suppressing microhomology-mediated end joining

Volume: 44, Issue: 12, Pages: 5743 - 5757
Published: Apr 29, 2016
Abstract
DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed. While MMEJ is suppressed by C-NHEJ, the relationship between HR and MMEJ is...
Paper Details
Title
A role for human homologous recombination factors in suppressing microhomology-mediated end joining
Published Date
Apr 29, 2016
Volume
44
Issue
12
Pages
5743 - 5757
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