Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies
Abstract
Purpose of review The CARMA1/BCL10/MALT1 (CBM) complex is a multimeric signaling complex controlling several important aspects of lymphocyte activation. Gain-of-function mutations in the genes encoding CBM proteins or their upstream regulators are associated with lymphoid malignancies, whereas loss-of-function mutations lead to immunodeficiency. This review reports on recent findings advancing our understanding of how CBM proteins contribute to...
Paper Details
Title
Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies
Published Date
Jul 1, 2016
Volume
23
Issue
4
Pages
402 - 409
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