Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires

Abstract
Elucidating how antigen exposure and selection shape the human antibody repertoire is fundamental to our understanding of B-cell immunity. We sequenced the paired heavy- and light-chain variable regions (VH and VL, respectively) from large populations of single B cells combined with computational modeling of antibody structures to evaluate sequence and structural features of human antibody repertoires at unprecedented depth. Analysis of a...
Paper Details
Title
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires
Published Date
May 10, 2016
Volume
113
Issue
19
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