Ehlers–Danlos Syndrome

The first comprehensive description of a syndrome comprising laxity and fragility of the skin associated with hypermobility of the large joints was published in 1892 by Tschernogobow1 in Moscow. With remarkable insight, he interpreted the cause of the phenotype as a systemic defect in connective tissue. However, as is common in medicine, those who came later are immortalized in the eponym, in this case Ehlers2 and Danlos,3 Danish and French...