Detection of High-grade Prostate Cancer Using a Urinary Molecular Biomarker–Based Risk Score

To reduce overdiagnosis and overtreatment, a test is urgently needed to detect clinically significant prostate cancer (PCa). To develop a multimodal model, incorporating previously identified messenger RNA (mRNA) biomarkers and traditional risk factors that could be used to identify patients with high-grade PCa (Gleason score ≥7) on prostate biopsy. In two prospective multicenter studies, urine was collected for mRNA profiling after digital...