Priming of neutrophils toward NETosis promotes tumor growth
Abstract
Neutrophils play a major role in cancer biology and both pro- and antitumoral functions of tumor-infiltrating neutrophils have been described. We have shown that tumors, by releasing G-CSF into the bloodstream, prime circulating neutrophils to form neutrophil extracellular traps (NETs) and we have detected the presence of NETs within the tumor microenvironment. Here, we report, using PAD4-deficient mice with a defect in neutrophil chromatin...
Paper Details
Title
Priming of neutrophils toward NETosis promotes tumor growth
Published Date
Feb 18, 2016
Journal
Volume
5
Issue
5
Pages
e1134073 - e1134073
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