Acyclovir Entrapped N-Trimethyl Chitosan Nanoparticles for Oral Bioavailability Enhancement
Abstract
Objective: The aim of the study was to evaluate a nanoparticulate system composed of Ntrimethyl chitosan (TMC) for improving the oral bioavailability of Acyclovir (ACV). Methods: TMC was prepared by methylation of chitosan and characterized by H-NMR spectroscopy. The ionic gelation method was used to prepare ACV loaded TMC nanoparticles. Non-everted sac technique was used to assess ex vivo permeation in rats. A pharmacokinetic study of the...
Paper Details
Title
Acyclovir Entrapped N-Trimethyl Chitosan Nanoparticles for Oral Bioavailability Enhancement
Published Date
Apr 5, 2016
Journal
Volume
12
Issue
3
Pages
378 - 385
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