Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
Abstract
With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma, non-small-cell lung cancer and kidney cancer, and additional immune checkpoints being targeted clinically, many questions still remain regarding the optimal use of drugs that block these checkpoint pathways. Defining biomarkers that predict therapeutic effects and adverse...
Paper Details
Title
Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
Published Date
Apr 15, 2016
Journal
Volume
16
Issue
5
Pages
275 - 287
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