Match!

Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population.

Published on Apr 21, 2016in PLOS ONE2.776
· DOI :10.1371/journal.pone.0153603
Yuping Zhang10
Estimated H-index: 10
(BNU: Beijing Normal University),
Jun Li13
Estimated H-index: 13
(BNU: Beijing Normal University)
+ 6 AuthorsHua Shu41
Estimated H-index: 41
(BNU: Beijing Normal University)
Abstract
The doublecortin domain-containing 2 (DCDC2) gene, which is located on chromosome 6p22.1, has been widely suggested to be a candidate gene for dyslexia, but its role in typical reading development over time remains to be clarified. In the present study, we explored the role of DCDC2 in contributing to the individual differences in reading development from ages 6 to 11 years by analysing data from 284 unrelated children who were participating in the Chinese Longitudinal Study of Reading Development (CLSRD). The associations of eight single nucleotide polymorphisms (SNPs) in DCDC2 with the latent intercept and slope of children’s reading scores were examined in the first step. There was significant support for an association of rs807724 with the intercept for the reading comprehension measure of reading fluency, and the minor “G” allele was associated with poor reading performance. Next, we further tested the rs807724 SNP in association with the reading ability at each tested time and revealed that, in addition to significant associations with the two main reading measures (reading fluency and Chinese character reading) over multiple testing occasions, this SNP also showed associations with reading-related cognitive skills, including morphological production, orthographic judgment and phonological processing skills (rapid number naming, phoneme deletion, and tone detection). This study provides support for DCDC2 as a risk gene for reading disability and suggests that this gene is also operative for typical reading development in the Han population.
  • References (43)
  • Citations (8)
📖 Papers frequently viewed together
66 Citations
43 Citations
65 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References43
Newest
#1Dorothy M. Chun (UCSB: University of California, Santa Barbara)H-Index: 21
#2Yan JiangH-Index: 1
Last. Rong YangH-Index: 1
view all 4 authors...
This paper reports on a study of 35 Mandarin Chinese learners who (1) created pitch curves of their spoken word tones and (2) compared their pitch curves with those of native speakers while practicing pronunciation. Following a pretest, the learners received training for 20–25 minutes weekly over nine weeks and took a posttest. Two types of data analyses were performed. First, native speakers of Mandarin auditorily rated the pretests and posttests. The ratings revealed that learners’ pronunciati...
12 CitationsSource
#1Y SunH-Index: 4
#2Yong GaoH-Index: 3
Last. Li Hai Tan (SZU: Shenzhen University)H-Index: 39
view all 11 authors...
Developmental dyslexia (DD) is characterized by difficulties in reading and spelling independent of intelligence, educational backgrounds and neurological injuries. Increasing evidences supported DD as a complex genetic disorder and identified four DD candidate genes namely DYX1C1, DCDC2, KIAA0319 and ROBO1. As such, DCDC2 and KIAA0319 are located in DYX2, one of the most studied DD susceptibility loci. However, association of these two genes with DD was inconclusive across different populations...
14 CitationsSource
#1Jessica A. R. Logan (OSU: Ohio State University)H-Index: 17
#2Sara A. Hart (FSU: Florida State University)H-Index: 20
Last. Stephen A. Petrill (OSU: Ohio State University)H-Index: 43
view all 6 authors...
The development of reading skills in typical students is commonly described as a rapid growth across early grades of active reading education, with a slowing down of growth as active instruction tapers. This study examined the extent to which genetics and environments influence these growth rates. Participants were 371 twin pairs, aged approximately 6 through 12, from the Western Reserve Reading Project. Development of word-level reading, reading comprehension, and rapid naming was examined usin...
27 CitationsSource
#1Micaela E. Christopher (CU: University of Colorado Boulder)H-Index: 7
#2Jacqueline Hulslander (CU: University of Colorado Boulder)H-Index: 12
Last. Richard K. Olson (CU: University of Colorado Boulder)H-Index: 64
view all 10 authors...
We explored the etiology of individual differences in reading development from post-kindergarten to post–4th grade by analyzing data from 487 twin pairs tested in Colorado. Data from three reading measures and one spelling measure were fit to biometric latent growth curve models, allowing us to extend previous behavioral genetic studies of the etiology of early reading development at specific time points. We found primarily genetic influences on individual differences at post–1st grade for all m...
23 CitationsSource
#1Micaela E. Christopher (CU: University of Colorado Boulder)H-Index: 7
#2Jacqueline Hulslander (CU: University of Colorado Boulder)H-Index: 12
Last. Richard K. Olson (Linköping University)H-Index: 64
view all 10 authors...
This first cross-country twin study of individual differences in reading growth from post-kindergarten to post-second grade analyzed data from 487 twin pairs from the United States, 267 twin pairs from Australia, and 280 twin pairs from Scandinavia. Data from two reading measures were fit to biometric latent growth models. Individual differences for the reading measures at post-kindergarten in the United States and Australia were due primarily to genetic influences and to both genetic and shared...
13 CitationsSource
#1Terry E. Duncan (Oregon Research Institute)H-Index: 45
#2Susan C. Duncan (Oregon Research Institute)H-Index: 45
Last. Lisa A. Strycker (Oregon Research Institute)H-Index: 42
view all 3 authors...
Contents: Preface. Introduction. Specification of the LGM. LGM, Repeated Measures ANOVA, and the Mixed Linear Model. Multivariate Representations of Growth and Development. Analyzing Growth in Multiple Populations. Accelerated Designs. Multilevel Longitudinal Approaches. Growth Mixture Modeling. Piecewise and Pooled Interruped Time Series LGMs. Latent Growth Curve Modeling With Categorical Variables. Missing Data Models. Latent Variable Framework for LGM Power Estimation. Testing Interaction Eff...
1,057 CitationsSource
#1Hong Li (BNU: Beijing Normal University)H-Index: 14
#2Hua Shu (BNU: Beijing Normal University)H-Index: 41
Last. Hong PengH-Index: 2
view all 5 authors...
Tasks tapping visual skills, orthographic knowledge, phonological awareness, speeded naming, morphological awareness and Chinese character recognition were administered to 184 kindergarteners and 273 primary school students from Beijing. Regression analyses indicated that only syllable deletion, morphological construction and speeded number naming were unique correlates of Chinese character recognition in kindergarteners. Among primary school children, the independent correlates of character rec...
125 CitationsSource
#1Thomas S. Scerri (Wellcome Trust Centre for Human Genetics)H-Index: 25
#2Alex G. Morris (Wellcome Trust Centre for Human Genetics)H-Index: 89
Last. Silvia Paracchini (Wellcome Trust Centre for Human Genetics)H-Index: 27
view all 8 authors...
Background Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared. Methods We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD ( MRPL19/C2ORF3 , KIAA0319, and DCDC2 ) and language impairment ( CMIP and ATP2C2 ) ca...
105 CitationsSource
Developmental dyslexia has been recognized as a distinct entity among learning disabilities as early as the late 1800s and its partially genetic nature has been firmly established by family and twin studies. The application of genetic mapping and molecular cloning methods has revealed specific genes that contribute to the genetic risk, but those known now do not yet suffice for explaining all of it. More importantly, the first genes, some of them found by the study of rare families, have indicat...
10 CitationsSource
#1Geert Poelmans (Radboud University Nijmegen Medical Centre)H-Index: 14
#2Jan K. Buitelaar (Radboud University Nijmegen Medical Centre)H-Index: 104
Last. Barbara Franke (Radboud University Nijmegen Medical Centre)H-Index: 76
view all 4 authors...
Developmental dyslexia is a common specific childhood learning disorder with a strong heritable component. Previous studies using different genetic approaches have identified several genetic loci and candidate genes for dyslexia. In this article, we have integrated the current knowledge on 14 dyslexia candidate genes suggested by cytogenetic findings, linkage and association studies. We found that 10 of the 14 dyslexia candidate genes (ROBO1, KIAA0319, KIAA0319L, S100B, DOCK4, FMR1, DIP2A, GTF2I...
95 CitationsSource
Cited By8
Newest
Source
#1Nicole Landi (UConn: University of Connecticut)H-Index: 18
#2Meaghan V. Perdue (UConn: University of Connecticut)H-Index: 3
Developmental disorders of spoken and written language are heterogeneous in nature with impairments observed across various linguistic, cognitive, and sensorimotor domains. These disorders are also associated with characteristic patterns of atypical neural structure and function that are observable early in development, often before formal schooling begins. Established patterns of heritability point toward genetic contributions, and molecular genetics approaches have identified genes that play a...
Source
#1Miao Li (UH: University of Houston)H-Index: 1
#3Jeffrey G. Malins (Yale University)H-Index: 6
Last. Jan C. Frijters (Brock University)H-Index: 14
view all 11 authors...
Children with poor reading comprehension despite typical word reading skills were examined using neuropsychological, genetic, and neuroimaging data collected from the Genes, Reading and Dyslexia Study of 1432 Hispanic American and African American children. This unexpected poor comprehension was associated with profound deficits in vocabulary, when compared to children with comprehension skills consistent with their word reading. Those with specific comprehension difficulties were also more like...
2 CitationsSource
#2Juan A. Hernández (ULL: University of La Laguna)H-Index: 8
Last. Manuel Francisco Carreiras Valiña (Ikerbasque)H-Index: 53
view all 10 authors...
Dyslexia and attention deficit hyperactivity disorder (ADHD) are two complex neuro-behaviorally disorders that co-occur more often than expected, so that reading disability has been linked to inattention symptoms. We examined 4 SNPs located on genes previously associated to dyslexia (KIAA0319, DCDC2, DYX1C1 and FOXP2) and 3 SNPs within genes related to ADHD (COMT, MAOA and DBH) in a cohort of Spanish children (N = 2078) that met the criteria of having one, both or none of these disorders (dyslex...
2 CitationsSource
#1Mellissa M. C. DeMille (Yale University)H-Index: 5
#2Kevin Tang (ZJU: Zhejiang University)H-Index: 3
Last. Jeffrey R. Gruen (Yale University)H-Index: 34
view all 11 authors...
DCDC2 is a gene strongly associated with components of the phonological processing system in animal models and in multiple independent studies of populations and languages. We propose that it may also influence population-level variation in language component usage. To test this hypothesis, we investigated the evolution and worldwide distribution of the READ1 regulatory element within DCDC2 , and compared its distribution with variation in different language properties. The mutational history of...
1 CitationsSource
#1Amanda R. Rendall (UConn: University of Connecticut)H-Index: 5
#2Peter A. Perrino (UConn: University of Connecticut)H-Index: 2
Last. Roslyn Holly Fitch (UConn: University of Connecticut)H-Index: 23
view all 4 authors...
1 CitationsSource
#1Pawan Sharma (Patan Academy of Health Sciences)H-Index: 3
#2Rajesh Sagar (AIIMS: All India Institute of Medical Sciences)H-Index: 43
Abstract Dyslexia also known as specific reading disorder is a complex heritable disorder with unexpected difficulty in learning to read and spell despite adequate intelligence, education, environment, and normal senses. Over past decades, researchers have attempted to characterize dyslexia neurobiological and genetic levels and unfold its pathophysiology. The genetic research on dyslexia has received attention in Asia from the last decade. Though limited by different constraints the studies fro...
1 CitationsSource
#1Thomas S. Scerri (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 25
#2Ellen Macpherson (St And: University of St Andrews)H-Index: 1
Last. Silvia Paracchini (St And: University of St Andrews)H-Index: 27
view all 15 authors...
Dyslexia is a specific impairment in learning to read and has strong heritability. An intronic deletion within the DCDC2 gene, with ~8% frequency in European populations, is increasingly used as a marker for dyslexia in neuroimaging and behavioral studies. At a mechanistic level, this deletion has been proposed to influence sensory processing capacity, and in particular sensitivity to visual coherent motion. Our re-assessment of the literature, however, did not reveal strong support for a role o...
7 CitationsSource
#1Sara MascherettiH-Index: 11
#2A De Luca (UNIPD: University of Padua)H-Index: 3
Last. Filippo ArrigoniH-Index: 14
view all 7 authors...
Neurogenetics of developmental dyslexia: from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms
28 CitationsSource