A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy
Abstract
The heart either hypertrophies or dilates in response to familial mutations in genes encoding sarcomeric proteins, which are responsible for contraction and pumping. These mutations typically alter calcium-dependent tension generation within the sarcomeres, but how this translates into the spectrum of hypertrophic versus dilated cardiomyopathy is unknown. By generating a series of cardiac-specific mouse models that permit the systematic tuning...
Paper Details
Title
A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy
Published Date
May 19, 2016
Journal
Volume
165
Issue
5
Pages
1147 - 1159
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