Future Treatments of NASH

NASH is a complex metabolic disease best understood by recognizing the sources and fates of major metabolic substrates (carbohydrates and fatty acids) and how their excess can lead to lipotoxic liver injury with a histological phenotype of NASH. With this perspective, targets of therapy can be predicted. This review summarizes recent clinical trial data and where these trials fit into the substrate overload lipotoxic liver injury paradigm of...