Adjust for Multiple Comparisons? It’s Not That Simple

Multiple comparisons are an unavoidable problem in medical research. The human organism is complex; in our efforts to understand how to maintain our health and treat our illnesses, we perform a tremendous number of scientific studies. Within the largest study units, there can be many subgroup comparisons, substudies, or ancillary studies; and within those study units, there still may be several potential outcome variables. That is obviously a...