Thrombin and fibrinogen γ' impact clot structure by marked effects on intrafibrillar structure and protofibril packing.
Abstract
Previous studies have shown effects of thrombin and fibrinogen γ′ on clot structure. However, structural information was obtained using electron microscopy, which requires sample dehydration. Our aim was to investigate the role of thrombin and fibrinogen γ′ in modulating fibrin structure under fully hydrated conditions. Fibrin fibers were studied using turbidimetry, atomic force microscopy, electron microscopy, and magnetic tweezers in purified...
Paper Details
Title
Thrombin and fibrinogen γ' impact clot structure by marked effects on intrafibrillar structure and protofibril packing.
Published Date
Jan 28, 2016
Journal
Volume
127
Issue
4
Pages
487 - 495
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