Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Abstract
The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We...
Paper Details
Title
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Published Date
Feb 9, 2018
Journal
Volume
359
Issue
6376
Pages
693 - 697
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