Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Published on May 1, 2016in Nature43.07
· DOI :10.1038/nature17946
Alexis C. Komor13
Estimated H-index: 13
Yongjoo Kim7
Estimated H-index: 7
+ 2 AuthorsDavid R. Liu73
Estimated H-index: 73
CRISPR/Cas9 DNA editing creates a double-stranded break in the target DNA, which can frequently generate random insertion or deletion of bases (indels); a new genome editing approach combining Cas9 with a cytidine deaminase is described here, which corrects point mutations more efficiently than canonical Cas9, while avoiding double-stranded breaks and indel formation.
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