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Marker of endothelial dysfunction may improve the early detection of insulin resistance and subclinical atherosclerosis

Published on Dec 1, 2015in Diabetology & Metabolic Syndrome 2.36
· DOI :10.1186/1758-5996-7-S1-A113
Bianca de Almeida Pititto1
Estimated H-index: 1
(UNIFESP: Federal University of São Paulo),
Fernando Flexa Ribeiro Filho8
Estimated H-index: 8
(UNIFESP: Federal University of São Paulo)
+ 3 AuthorsSandra Roberta Gouvea Ferreira17
Estimated H-index: 17
(UNIFESP: Federal University of São Paulo)
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Abstract
Materials and methods A sample of 998 individuals from the ELSA-Brazil (35-54 yrs.) without cardiovascular disease or diabetes was stratified according to E-selectin tertiles. Traditional risk factors, inflammatory markers and categories of coronary artery calcium (CAC) score were evaluated across the tertiles by ANOVA or chi-squared test. In linear regression models, associations of E-selectin levels with insulin resistance index, adjusted for age, sex and adiposity were tested.
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Published on Apr 30, 2019in International Journal of Obesity 4.51
Antonella Marucci12
Estimated H-index: 12
(Casa Sollievo della Sofferenza),
Alessandra Antonucci (Sapienza University of Rome)+ 4 AuthorsRosa Di Paola19
Estimated H-index: 19
(Casa Sollievo della Sofferenza)
A better understanding of adipose tissue biology is crucial to tackle insulin resistance and eventually coronary heart disease and diabetes, leading causes of morbidity and mortality worldwide. GALNT2, a GalNAc-transferase, positively modulates insulin signaling in human liver cells by down-regulating ENPP1, an insulin signaling inhibitor. GALNT2 expression is increased in adipose tissue of obese as compared to that of non-obese individuals. Whether this association is secondary to a GALNT2-insu...
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Published on Jan 1, 2016in Amino Acids 2.52
Caroline B. Quines6
Estimated H-index: 6
(UFSM: Universidade Federal de Santa Maria),
Suzan Gonçalves Rosa7
Estimated H-index: 7
(UFSM: Universidade Federal de Santa Maria)
+ 6 AuthorsCristina W. Nogueira51
Estimated H-index: 51
(UFSM: Universidade Federal de Santa Maria)
The metabolic syndrome is a group of metabolic alterations considered a worldwide public health problem. Organic selenium compounds have been reported to have many different pharmacological actions, such as anti-hypercholesterolemic and anti-hyperglycemic. The aim of this study was to evaluate the effect of p-chloro-diphenyl diselenide (p-ClPhSe)2, an organic selenium compound, in a model of obesity induced by monosodium glutamate (MSG) administration in rats. The rats were treated during the fi...
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