Dissolution Efficiency and Design Space for an Oral Pharmaceutical Product in Tablet Form

The primary drug quality requirements—safety, efficacy, and reliability—for oral pharmaceutical products in tablet form, translate into bioavailability, tablet weight, and tablet strength. The bioavailability of an oral drug, i.e., the amount of the drug that can reach the systemic circulation, is dependent on the drug permeation rate through the epithelial membrane or on dissolution rate, in the case of bioequivalence. Thus, the critical...