Current Threat of Triclabendazole Resistance in Fasciola hepatica

TCBZ-R in Fasciola hepatica has now been demonstrated on at least 30 properties worldwide. TCBZ-R in F. hepatica is now reported in cattle in Australia and South America. Human infections with TCBZ-resistant F. hepatica have been reported in The Netherlands, Chile, Turkey, and Peru. The coproantigen ELISA may allow an estimate of the intensity of fluke infection in livestock. The mode of action of TCBZ may involve inhibition of adenylate cyclase...