Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice
Abstract
Apathy is an early and common neuropsychiatric syndrome in Alzheimer's disease (AD) patients. In clinical trials, apathy is associated with decreased motor activity that can be monitored by actigraphy. The triple transgenic mouse AD model (3xTgAD) has been shown to recapitulate the biochemical lesions as well as many of the synaptic and cognitive alterations associated with AD. In the present work we found that these mice also develop an early...
Paper Details
Title
Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice
Published Date
Jun 2, 2016
Journal
Volume
13
Issue
8
Pages
942 - 949
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