Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline
Volume: 40, Issue: 3, Pages: 151 - 161
Published: May 1, 2015
Abstract
Background:
Alzheimer disease is characterized by cognitive decline, senile plaques of β-amyloid (Aβ) peptides, neurofibrillary tangles composed of hyperphosphorylated τ proteins and neuronal loss. Aβ and τ are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are serine-threonine protein kinases activated by phosphorylation and involved in neuronal death.Methods:
In this study, Western blots,...Paper Details
Title
Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline
Published Date
May 1, 2015
Volume
40
Issue
3
Pages
151 - 161
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Notes
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