Original paper
Nickel Superoxide Dismutase: Structural and Functional Roles of His1 and Its H-Bonding Network
Abstract
Crystal structures of nickel-dependent superoxide dismutases (NiSODs) reveal the presence of a H-bonding network formed between the NH group of the apical imidazole ligand from His1 and the Glu17 carboxylate from a neighboring subunit in the hexameric enzyme. This interaction is supported by another intrasubunit H-bond between Glu17 and Arg47. In this study, four mutant NiSOD proteins were produced to experimentally evaluate the roles of this...
Paper Details
Title
Nickel Superoxide Dismutase: Structural and Functional Roles of His1 and Its H-Bonding Network
Published Date
Jan 21, 2015
Journal
Volume
54
Issue
4
Pages
1016 - 1027
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Notes
History