Biomineralized Anisotropic Gold Microplate–Macrophage Interactions Reveal Frustrated Phagocytosis-like Phenomenon: A Novel Paclitaxel Drug Delivery Vehicle

This study reports a facile biomineralization route for gold microplates (GMPs) synthesis using bovine serum albumin (BSA) as a reductant and stabilizing agent. Adding BSA to HAuCl4 solution yields spontaneous versatile anisotropic and partially hollow GMPs upon aging. We hypothesize that the instantaneous protein denaturation at low pH enabled access to serine and threonine hydroxyl, and sulfhydryl groups of BSA, which act as a reductant and...