Match!

Memories of virus-specific CD8 + T cells

Published on Apr 1, 2004in Immunology and Cell Biology3.947
· DOI :10.1046/j.0818-9641.2004.01241.x
Peter C. Doherty97
Estimated H-index: 97
(University of Melbourne),
Stephen J. Turner45
Estimated H-index: 45
(University of Melbourne)
Abstract
This brief review focuses on the way that our understanding of virus-specific CD8 + T-cell-mediated immunity evolved, giving particular attention to the early impact of the program at the Australian National University. The story developed through a sequence of distinct eras, each of which can be defined in the context of the technologies available at that time. The progress has been enormous, but there is a great deal still to be learned. A particular challenge is to use what we know for human benefit.
  • References (90)
  • Citations (4)
References90
Newest
We examined the in vivo immune response of infants to natural respiratory syncytial virus (RSV) infection through analysis of cytokine levels in nasal lavage fluid and stimulated peripheral blood mononuclear cells. Eighty-eight babies with at least one parent with atopy and asthma were prospectively studied through their first winter. Twenty-eight infants had an upper respiratory tract infection where RSV was detected, of whom nine developed signs of acute bronchiolitis. Nasal lavage specimens w...
273 CitationsSource
#1Hanna Juntti (University of Oulu)H-Index: 5
#2Jorma Kokkonen (University of Oulu)H-Index: 30
Last. Matti Uhari (University of Oulu)H-Index: 51
view all 6 authors...
Background: Respiratory syncytial virus (RSV) causes postbronchiolitic wheezing but its role in allergic sensitization is controversial. The purpose of the study was to examine the effect of an early RSV infection on allergic sensitization. Methods: Seventy-six subjects were examined 6–10 years after hospitalization for RSV infection during the first year of life. Fifty-one subjects (68%) attended clinical studies and 25 filled in a questionnaire. The study protocol included lung function, skin-...
45 CitationsSource
#1Rosalyn J. Singleton (CDC: Centers for Disease Control and Prevention)H-Index: 36
#2Greg Redding (UW: University of Washington)H-Index: 36
Last. Jay C. Butler (CDC: Centers for Disease Control and Prevention)H-Index: 55
view all 14 authors...
Objective. In 1993-1996, we conducted a nested case-control study to determine risk factors for hospitalization with respiratory syncytial virus (RSV) infection among Alaska Native infants and young chil- dren. In the current study, we returned to former RSV case-patients and their control subjects during 1999 -2001 to determine whether children who are hospitalized with RSV at <2 years of age are more likely to develop chronic respiratory conditions. Methods. For each former RSV case-patient an...
66 CitationsSource
#1Stephen J. Turner (St. Jude Children's Research Hospital)H-Index: 45
#2Gabriela Diaz (St. Jude Children's Research Hospital)H-Index: 7
Last. Peter C. Doherty (St. Jude Children's Research Hospital)H-Index: 97
view all 4 authors...
Abstract The spectrum of TCR Vβ usage is compared for primary and recall CD8 + D b PA 224 + T cell responses in mice with influenza pneumonia. Single-cell RT-PCR established that the same clonotypes were present in the lymphoid tissue and in the virus-infected lung. Longitudinal analysis indicated that the memory TCR repertoire reflects the primary response, with no decrease in diversity prior to (or after) secondary challenge. The re-engagement of memory T cells looked to be stochastic in this ...
123 CitationsSource
#1Jacques Banchereau (Baylor University Medical Center)H-Index: 133
#2Sophie Paczesny (Baylor University Medical Center)H-Index: 35
Last. Anna Karolina Palucka (Baylor University Medical Center)H-Index: 57
view all 7 authors...
187 Citations
Influenza virus infection activates cytolytic T lymphocytes (CTL) that contribute to viral clearance by releasing perforin and granzymes from cytoplasmic granules. Virus-specific, perforin-dependent CD8+ CTL were detected in freshly isolated cells from the mouse lung parenchyma but not from the mediastinal lymph nodes (MLN), where they are primed, or from the spleen during primary influenza virus infection. To determine whether this difference was due to the low frequency or incomplete maturatio...
109 CitationsSource
#1Arthur M. Feldman (Thomas Jefferson University)H-Index: 60
#2Toshiaki Kadokami (University of Pittsburgh)H-Index: 10
Last. Charles F. McTiernan (University of Pittsburgh)H-Index: 38
view all 5 authors...
A decade ago, investigators first recognized that levels of the proinflammatory cytokine, tumor necrosis factor-a (TNFa), were elevated in patients with heart failure. Subsequent studies in isolated myocytes and in mice that overexpress TNF demonstrated that TNF could recapitulate the cellular biology and biochemistry of the failing human heart. In addition, anticytokine strategy in experimental models effected dramatic changes in the heart failure phenotype. The initial enthusiasm that was enge...
13 CitationsSource
#1Barbara Cannella (Yeshiva University)H-Index: 30
#2Stefanie Gaupp (Yeshiva University)H-Index: 3
Last. Cedric S. Raine (Yeshiva University)H-Index: 92
view all 4 authors...
The integrin VLA-4 has been shown to play a key role in the entry of antigen-specific T cells into the CNS during autoimmune demyelination. Treatment of animals with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, with antibodies to VLA-4 is known to suppress acute disease. In the present study, a synthetic antagonist of VLA-4 (TBC 3486) was injected subcutaneously into mice adoptively sensitized for chronic relapsing EAE. TBC 3486 was administered daily for 14 da...
21 CitationsSource
#1Susan M. Kaech (Emory University)H-Index: 65
#2Scott E. Hemby (Emory University)H-Index: 33
Last. Rafi Ahmed (Emory University)H-Index: 124
view all 4 authors...
How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not...
776 CitationsSource
#1Gabrielle T. BelzH-Index: 67
#2Dominik WodarzH-Index: 40
Last. Peter C. DohertyH-Index: 97
view all 5 authors...
The primary influenza A virus-specific CD8+-T-cell responses measured by tetramer staining of spleen, lymph node, and bronchoalveolar lavage (BAL) lymphocyte populations were similar in magnitude for conventional I-Ab+/+ and CD4+-T-cell-deficient I-Ab−/− mice. Comparable levels of virus-specific cytotoxic-T-lymphocyte activity were detected in the inflammatory exudate recovered by BAL following challenge. However, both the size of the memory T-cell pool and the magnitude of the recall response i...
252 CitationsSource
Cited By4
Newest
#1Anurag Sharma (Purdue University)H-Index: 9
#2Manish Tandon (Purdue University)H-Index: 19
Last. Suresh K. Mittal (Purdue University)H-Index: 34
view all 6 authors...
The absence of preexisting immunity against porcine adenovirus (Ad) serotype 3 (PAd3) and bovine Ad serotype 3 (BAd3) in humans makes them attractive alternatives to human Ad serotype 5 (HAd5) vectors. To determine whether there is significant cross-reactivity among HAd5, BAd3, and PAd3 at the level of cell-mediated immune responses, BALB/c mice were inoculated intraperitoneally with wild type (WT) or replication-defective (RD) HAd5, BAd3, or PAd3. Thirty-five days after the first inoculation, c...
32 CitationsSource
#1Chris D. Platsoucas (TU: Temple University)H-Index: 37
#2Emilia L. Oleszak (TU: Temple University)H-Index: 18
We are investigating the hypothesis that most human autoimmune diseases are specific antigen-driven T-cell diseases. T-cell clones responding to specific antigenic epitopes are responsible for the initiation and/or the propagation of these diseases. Similarly, specific antigen-driven T-cell responses are responsible for the rejection of organ allografts and the immune response to tumors. Activated T cells provide the “engine” for the chronic inflammation that is associated with autoimmune diseas...
7 CitationsSource
#1Peter C. DohertyH-Index: 97
8 CitationsSource