Protective effects of chitosan and liposomal formulation for enzymatic degradation of insulin and their absorption promoting effects in intestinal mucous layer.

We have previously demonstrated that oral administration of chitosan-coated liposomes containing insulin (CS-Lip Ins) lead to a long-term reduction of blood glucose level in rats. In this study, we investigated protective effects of chitosan and liposomal formulation on enzymatic degradation of insulin and promoting effect of chitosan in absorption of insulin in the gastrointestinal tract. A homogenized mucus layer including epithelial cells of...