[18F]FE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?

Cécile Philippe; Daniela Haeusler; Thomas Scherer; Clemens Fürnsinn; Markus Zeilinger; Wolfgang Wadsak; Karem Shanab; Helmut Spreitzer; Marcus Hacker; Markus Mitterhauser

doi:https://doi.org/10.1186/s13550-016-0186-7

doi.org/10.1186/s13550-016-0186-7

[18F]FE@SNAP—a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?

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..., Markus Mitterhauser

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EJNMMI Research3.20

Volume: 6, Issue: 1

Published: Apr 1, 2016

Abstract

The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a major interest in in vivo imaging of this receptor. A PET tracer would allow non-invasive in vivo visualization and quantification of the MCHR1. The aim of the study was the ex vivo evaluation of the MCHR1 ligand [18F]FE@SNAP as a potential PET...