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The gut-brain axis interactions during heat stress and avian necrotic enteritis

Published on May 1, 2016in Poultry Science2.03
· DOI :10.3382/ps/pew021
Atilio Sersun Calefi7
Estimated H-index: 7
,
Juliana Garcia da Silva Fonseca4
Estimated H-index: 4
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
Cite
Abstract
The gut-brain axis is known to modulate behavioral and immune responses in animals; evidence supporting this modulation in chickens, however, is elusive. Here, we analyzed the effects of heat stress and/orClostridium perfringens (CP) infection on behavior, intestinal morphology, brain activity, and corticosterone serum levels in chickens. Broilers were randomly divided into 5 equal groups: a naive group (N), a thioglycolate group (T), a thioglycolate heat-stressed group (T/HS35), an infected group (I), and an infected/stressed (I/HS35) group. Broilers in the I and I/HS35 groups were experimentally infected withClostridium perfringensfrom the 15th to the 19th day of life. Heat stress (35±1°C) was constantly applied to the broilers in the stressed groups from the 14th to the 19th day of life. Our data showed that heat stress andC. perfringensinfection produced significant differential responses in the chickens' behavior and in c-fosexpression in the paraventricular nucleus of the hypothalamus (PVN), nucleus taenia of the amygdala (Tn), medial preoptic area (POM), andglobus pallidus (GP) of the chickens. Heat stress ameliorated some of the intestinal lesions and the neuroendocrine changes induced byC. perfringensin the birds. Our results suggest the existence of clear relationships between the degree of intestinal lesions, the chickens' behavioral outcomes, brain activity, and serum levels of corticosterone. Together, they reinforce the importance of neuroimmunomodulation and especially of brain-gut axis interactions.
  • References (51)
  • Citations (8)
Cite
References51
Newest
Published on Jun 1, 2014in Poultry Science2.03
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Bruno Takashi Bueno Honda3
Estimated H-index: 3
(USP: University of São Paulo)
+ 7 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Published on Oct 10, 2013in Blood16.56
Emmanuel L. Gautier26
Estimated H-index: 26
(WashU: Washington University in St. Louis),
Stoyan Ivanov20
Estimated H-index: 20
(WashU: Washington University in St. Louis)
+ 1 AuthorsGwendalyn J. Randolph72
Estimated H-index: 72
(WashU: Washington University in St. Louis)
Chronic inflammatory diseases such as atherosclerosis are characterized by an accumulation of macrophages. To design therapies that would reduce macrophage burden during disease, understanding the cellular and molecular mechanisms that regulate macrophage removal from sites of resolving inflammation is critical. Although past studies have considered the local death of macrophages or the possibility that they emigrate out of inflammatory foci, methods to quantify death or emigration have never be...
Published on Oct 1, 2012in Avian Pathology1.96
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
A.V. Gomes3
Estimated H-index: 3
(USP: University of São Paulo)
+ 5 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Stressful situations reduce the welfare, production indices and immune status of chickens. Salmonella spp. are a major zoonotic pathogens that annually cause over 1 billion infections worldwide. We therefore designed the current experiment to analyse the effects of 31±1°C heat stress (HS) (from 35 to 41 days) on performance parameters, Salmonella invasion and small intestine integrity in broiler chickens infected with Salmonella Enteritidis. We observed that HS decreased body weight gain and fee...
Published on Jun 1, 2012in Journal of Animal Science1.70
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
M. V. Rodrigues1
Estimated H-index: 1
(USP: University of São Paulo)
+ 5 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Studies on the environmental conse- quences of stress are relevant for economic and animal welfare reasons. We recently reported that long-term heat stressors (31 ± 1oC and 36 ± 1oC for 10 h/d) applied to broiler chickens (Gallus gallus domesticus) from d 35 to 42 of life increased serum corticosterone con- centrations, decreased performance variables and the macrophage oxidative burst, and produced mild, mul- tifocal acute enteritis. Being cognizant of the relevance of acute heat stress on trop...
Published on Jan 1, 2011in Frontiers in Physiology3.20
Sue Grenham2
Estimated H-index: 2
(UCC: University College Cork),
Gerard Clarke44
Estimated H-index: 44
(UCC: University College Cork)
+ 1 AuthorsTimothy G. Dinan80
Estimated H-index: 80
(UCC: University College Cork)
Bidirectional signalling between the gastrointestinal tract and the brain is regulated at neural, hormonal and immunological levels. This construct is known as the brain-gut axis and is vital for maintaining homeostasis. Bacterial colonisation of the intestine plays a major role in the post-natal development and maturation of the immune and endocrine systems. These processes are key factors underpinning central nervous system (CNS) signalling. Recent research advances have seen a tremendous impr...
Published on Jan 1, 2011in Frontiers in Physiology3.20
Fabien Bornert5
Estimated H-index: 5
(UDS: University of Strasbourg),
Philippe Choquet10
Estimated H-index: 10
(UDS: University of Strasbourg)
+ 6 AuthorsMatthieu Schmittbuhl14
Estimated H-index: 14
(UDS: University of Strasbourg)
X-linked hypohidrotic ectodermal dysplasia (XLHED) is a genetic disorder due to a mutation of Eda gene and mainly characterized by an absence or deficient function of hair, teeth and sweat glands, and craniofacial dysmorphologies. Although the tooth abnormalities in Tabby mutant mice -the murine model of XLHED- have been extensively studied, the characterization of the craniofacial complex, and especially the mandibular morphology has received less attention. From 3D microCT reconstructions of t...
Published on Sep 1, 2010in Poultry Science2.03
W.M. Quinteiro-Filho11
Estimated H-index: 11
,
A. Ribeiro12
Estimated H-index: 12
+ 5 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
Studies on environmental consequences of stress on ammal production have grown substantially in the last few years for economic and animal welfare reasons. Physiological, hormonal, and immunological deficits as well as increases in animals' susceptibility to diseases have been reported after different stressors in broiler chickens. The aim of the current experiment is to describe the effects of 2 different heat stressors (31 ± 1 and 36 ± 1°C/10 h per d) applied to broiler chickens from d 35 to 4...
Published on May 1, 2010in Veterinary Microbiology2.79
Kerry K. Cooper11
Estimated H-index: 11
(UA: University of Arizona),
J. Glenn Songer39
Estimated H-index: 39
(UA: University of Arizona)
Abstract Poultry necrotic enteritis (NE) has, over recent decades, been prevented and treated by addition of antimicrobials to poultry feed. Recent bans of antimicrobial growth promoters in feed, as well as other factors, have led to a slow, worldwide re-emergence of NE. Understanding of pathogenesis of NE has been hampered by lack of a consistent and effective experimental model in which virulence of strains can be reliably evaluated, with an endpoint yielding lesions comparable to those seen i...
Published on Apr 1, 2010in Poultry Science2.03
Wayne J. Kuenzel16
Estimated H-index: 16
(UA: University of Arkansas),
A. Jurkevich1
Estimated H-index: 1
(UA: University of Arkansas)
Published on Jan 1, 2010in Neuroimmunomodulation1.35
Frederico Azevedo Costa-Pinto13
Estimated H-index: 13
(USP: University of São Paulo),
João Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Stress has long been recognized as a putative modulator of immunity. Several clinical and experimental reports point to a role of physical and psychological stressors on progression or resistance to disease. Nonetheless, literature in this field is sometimes controversial due to the wide variety of stressors employed and parameters of immunity analyzed. This variation should not be considered a consequence of methodological inaccuracy. The stress response, although theoretically stereotyped in n...
Cited By8
Newest
Published on Jun 21, 2019in Poultry Science2.03
Jerine A.J. van der Eijk2
Estimated H-index: 2
(WUR: Wageningen University and Research Centre),
Hugo de Vries2
Estimated H-index: 2
(WUR: Wageningen University and Research Centre)
+ 5 AuthorsA. Lammers14
Estimated H-index: 14
(WUR: Wageningen University and Research Centre)
Feather pecking (FP), a damaging behavior where laying hens peck and pull at feathers of conspecifics, is multifactorial and has been linked to numerous behavioral and physiological characteristics. The gut microbiota has been shown to influence host behavior and physiology in many species, and could therefore affect the development of damaging behaviors, such as FP. Yet, it is unknown whether FP genotypes (high FP [HFP] and low FP [LFP] lines) or FP phenotypes (i.e., individuals differing in FP...
Published on Apr 1, 2019in Research in Veterinary Science1.75
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
Catarina Augusta de Queiroz Nunes (USP: University of São Paulo)+ 3 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract Heat stress has a relevant effect on animal health and productivity. Stress and environmental changes can contribute to disease development, such as avian necrotic enteritis (NE). The goal of this study was to analyze the effects of heat stress applied to broiler chickens in an experimental model of co-infection with Clostridium perfringens and Eimeria spp. Therefore, the current study was designed to analyze the effect of heat stress to broiler chickens in an experimental model of infe...
Published on Apr 1, 2019in Veterinary Immunology and Immunopathology1.85
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo),
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo)
+ 9 AuthorsPaulo César Maiorka10
Estimated H-index: 10
(USP: University of São Paulo)
Abstract Information on the dynamics of the chicken immune system during bacterial or parasite challenge in the presence or absence of stressful situations may provide a better understanding of the complex mechanisms behind these diseases. Necrotic enteritis (NE) had been controlled previously by the proper use of antimicrobial agents; however, more recently, NE has reemerged in many countries. The imposed restrictions on antimicrobial use and/or the intensive productive programs implemented by ...
Published on Jan 9, 2019in Veterinary Sciences
Atilio Sersun Calefi7
Estimated H-index: 7
,
Juliana Garcia da Silva Fonseca4
Estimated H-index: 4
+ 6 AuthorsJoão Palermo-Neto7
Estimated H-index: 7
Heat stress has been related to the impairment of behavioral and immunological parameters in broiler chickens. However, the literature is not clear on the involvement of neuroimmune interactions in a heat stress situation associated with bacterial and parasitic infections. The present study evaluated the production of monoamines and their metabolites in brain regions (rostral pallium, hypothalamus, brain stem, and midbrain) in broiler chickens submitted to chronic heat stress and/or infection an...
Published on Nov 2, 2018in Avian Pathology1.96
V. Tsiouris2
Estimated H-index: 2
(A.U.Th.: Aristotle University of Thessaloniki),
I. Georgopoulou7
Estimated H-index: 7
(A.U.Th.: Aristotle University of Thessaloniki)
+ 3 AuthorsP. Fortomaris5
Estimated H-index: 5
(A.U.Th.: Aristotle University of Thessaloniki)
ABSTRACTHeat stress is a physical environmental stressor, which can affect performance, health and welfare of poultry. The present study investigates the effect of cyclic acute heat stress as a predisposing factor for necrotic enteritis in broiler chicks in an experimental challenge model. Two hundred and forty broiler chicks were randomly allocated to four treatment groups, as follows: group A served as negative control (25°C), group B birds were subjected to cyclic acute heat stress (35°C), gr...
Published on Sep 1, 2017in Worlds Poultry Science Journal1.36
Atilio Sersun Calefi7
Estimated H-index: 7
,
W.M. Quinteiro-Filho11
Estimated H-index: 11
+ 1 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
Published on Apr 1, 2017in Livestock Science1.38
Hirofumi Okuyama1
Estimated H-index: 1
(Ehime University),
Md. Sakirul Islam Khan9
Estimated H-index: 9
(Ehime University)
+ 1 AuthorsTetsuya Tachibana25
Estimated H-index: 25
(Ehime University)
Abstract High ambient temperature, a major stressor, impairs the growth of chickens. In this study, we examined the effect of heat exposure on the mRNA expression of various growth related genes, such as growth hormone (GH), insulin-like growth factor-1 (IGF1), GH-releasing hormone (GHRH), thyrotropin-releasing hormone (TRH), and somatostatin (SST) in layer-type chickens ( Gallus gallus domesticus ) at an early age. In addition, we examined the reactivity of the corticotrophin-releasing hormone ...
Published on Apr 1, 2017in Veterinary Immunology and Immunopathology1.85
W.M. Quinteiro-Filho11
Estimated H-index: 11
(USP: University of São Paulo),
Atilio Sersun Calefi7
Estimated H-index: 7
(USP: University of São Paulo)
+ 6 AuthorsJoão Palermo-Neto29
Estimated H-index: 29
(USP: University of São Paulo)
Abstract A high ambient temperature is a highly relevant stressor in poultry production. Heat stress (HS) has been reported to reduce animal welfare, performance indices and increase Salmonella susceptibility. Salmonella spp. are major zoonotic pathogen that cause over 1 billion of human infections worldwide annually. Therefore, the current study was designed to analyze the effect of heat stress on Salmonella infection in chickens through modulation of the immune responses. Salmonella Enteritidi...