Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMAc) to noncovalently anchor liposomes to polymer layers. We subsequently assembled ∼1 μm diameter PMAc-based capsosomes, polymer hydrogel capsules that contain up to ∼2000 liposomal subcompartments, and...