The amyloid hypothesis of Alzheimer's disease at 25 years

Volume: 8, Issue: 6, Pages: 595 - 608
Published: Jun 1, 2016
Abstract
null Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early, often initiating factor in Alzheimer9s disease (AD). Confirmation that presenilin is the catalytic site of γ‐secretase has provided a linchpin: all dominant mutations causing early‐onset AD...
Paper Details
Title
The amyloid hypothesis of Alzheimer's disease at 25 years
Published Date
Jun 1, 2016
Volume
8
Issue
6
Pages
595 - 608
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