Allospecific CD154+ B Cells Associate With Intestine Allograft Rejection in Children

Background. As a significant determinant of T- and B-cell cooperation, CD154 has been used to identify allospecific T-cytotoxic memory cells (TcM) for rejection risk assessment with high sensitivity or specificity but not for alloreactive B-cells, especially among recipients predisposed to acute cellular and humoral rejection, that is, children with intestinal transplantation (ITx). Methods. Single blood samples from 32 pediatric ITx after...