Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Blood20.30
Volume: 127, Issue: 11, Pages: 1481 - 1492
Published: Mar 17, 2016
Abstract
Key Points Pomalidomide selectively targets BCL11A and SOX6 to induce γ-globin synthesis. The mechanism of action of pomalidomide during erythropoiesis is independent of IKZF1 degradation, in contrast to multiple...
Paper Details
Title
Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors
Published Date
Mar 17, 2016
Journal
Volume
127
Issue
11
Pages
1481 - 1492
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