Rapid Determination of Fibrinogen by Thrombokinetics

We have demonstrated that under specific conditions the maximal rate of change in optical density (Vmax∆OD) of plasma resulting from addition of thrombin with subsequent conversion of fibrinogen to fibrin is directly related to the concentration of clottable fibrinogen. Plasma fibrinogen concentration determined in seconds by this thrombokinetic analysis correlated significantly (r > 0.95, p < 0.001) with fibrinogen quantitation measured by...