Original paper
BRG1 promotes DNA double-strand break repair by facilitating the replacement of RPA with RAD51
Abstract
DNA double-strand breaks (DSBs) are a type of lethal DNA damage. The repair of DSBs requires tight coordination between the factors modulating chromatin structure and the DNA repair machinery. BRG1, the ATPase subunit of the chromatin remodelling complex Switch/Sucrose non-fermentable (SWI/SNF), is often linked to tumorigenesis and genome instability, and its role in DSB repair remains largely unclear. In the present study, we show that BRG1 is...
Paper Details
Title
BRG1 promotes DNA double-strand break repair by facilitating the replacement of RPA with RAD51
Published Date
Jan 1, 2014
Journal
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Notes
History