Conformationally Constrained Ac-His-D-Nal(2’)-Nle-Trp-NH2 Analogues Leads to Selective Melanotropins

Skin pigmentation shows substantial variation within human populations and within regional groupings or races. High levels of UVR can lead to skin damage such as sunburn or skin cancer, as well as the breakdown of folic acid. Melanin provides some protection from UVR induced damage [1]. MC1-R has a well-defined role in the regulation of skin pigmentation, provides protection against damaging and mutagenic effects of UV radiation (skin cancer)...