Complete activation of autophagic process attenuates liver injury and improves survival in septic mice.

Published on Mar 1, 2014in Shock3.083
· DOI :10.1097/SHK.0000000000000111
Chih-Wen Lin7
Estimated H-index: 7
Steven Lo8
Estimated H-index: 8
+ 7 AuthorsYa-Ching Hsieh5
Estimated H-index: 5
  • References (30)
  • Citations (25)
📖 Papers frequently viewed together
80 Citations
8 Authors (Steven Lo, ..., Ya-Ching Hsieh)
58 Citations
57 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Waka Takahashi (Chiba University)H-Index: 3
#2Eizo Watanabe (Chiba University)H-Index: 18
Last. Masahiko Hatano (Chiba University)H-Index: 36
view all 9 authors...
57 CitationsSource
#1Yu-Ting Yen (PRC: China Medical University (PRC))H-Index: 7
#2Horng Ren Yang (PRC: China Medical University (PRC))H-Index: 16
Last. Chi-Hsun Hsieh (PRC: China Medical University (PRC))H-Index: 1
view all 7 authors...
Background Autophagy plays distinct roles in apoptosis and the inflammatory process. Understanding the role of autophagy in sepsis-induced acute lung injury (ALI) may provide new insights into developing novel therapeutic strategies for this group of patients. The aim of this study was to investigate the regulation of autophagy in the septic lung and to use pharmacologic agents to modulate autophagy to study its functional significance. Methods Mice were subjected to cecal ligation and puncture ...
56 CitationsSource
#1Steven LoH-Index: 8
#2Shyng-Shiou F. YuanH-Index: 18
Last. Ya-Ching HsiehH-Index: 5
view all 8 authors...
58 CitationsSource
#1Hong-Min NiH-Index: 28
#2Hartmut JaeschkeH-Index: 91
Last. Wen-Xing DingH-Index: 48
view all 3 authors...
Autophagy is a lysosomal degradation pathway for bulk cytosolic proteins and damaged organelles, and is well known to act as a cell survival mechanism. Acetaminophen (APAP) overdose can cause liver injury in animals and humans by inducing necrosis due to mitochondrial damage. We recently found that pharmacological induction of autophagy by rapamycin protects against, whereas pharmacological suppression of autophagy by chloroquine exacerbates, APAP-induced liver injury in mice. Autophagy is induc...
16 CitationsSource
#1Elizabeth A. Mann (University of Texas Health Science Center at Houston)H-Index: 11
#2Mara M. Baun (University of Texas Health Science Center at Houston)H-Index: 10
Last. Charles E. WadeH-Index: 72
view all 4 authors...
Abstract : The purpose of this systematic review of the literature was to determine the association of sepsis with mortality in the severely injured adult patient by means of a comparative analysis of sepsis in burn and trauma injury with other critically ill populations. The MEDLINE (PubMed), Cochrane Library, and ProQuest databases were searched. The following keywords and MeSH headings were used: sepsis, septicemia, septic shock, epidemiology, burns, thermal injury, trauma, wounds and injurie...
71 CitationsSource
#1Hyun S. Kim (University of Pittsburgh)H-Index: 79
#2Mark E. Bernard (University of Pittsburgh)H-Index: 9
Last. Joel S. Greenberger (University of Pittsburgh)H-Index: 63
view all 10 authors...
AbstractPurpose: To determine whether Carbamazepine (CBZ) is a radiation protector and/or mitigator.Materials and methods: Murine hematopoietic progenitor 32D cl 3 cells were incubated in 1, 10, or 100 μM CBZ 1 h before or immediately after 0–8 Gy irradiation and assayed for clonogenic survival. Autophagy was assayed by immunoblot for microtubule-associated protein light chain 3 (LC3). In vivo radioprotection and mitigation were determined with C57BL/6NTac mice.Results: CBZ treatment at 1, 10 or...
23 CitationsSource
#1Yoshihiro Inami (Juntendo University)H-Index: 4
#2Shunhei Yamashina (Juntendo University)H-Index: 23
Last. Sumio Watanabe (Juntendo University)H-Index: 41
view all 7 authors...
Autophagy, one of protein degradation system, contributes to maintain cellular homeostasis and cell defense. Recently, some evidences indicated that autophagy and lipid metabolism are interrelated. Here, we demonstrate that hepatic steatosis impairs autophagic proteolysis. Though accumulation of autophagosome is observed in hepatocytes from ob/ob mice, expression of p62 was augmented in liver from ob/ob mice more than control mice. Moreover, degradation of the long-lived protein leucine was sign...
51 CitationsSource
#1Chi-Hsun HsiehH-Index: 2
#2Pei-Ying PaiH-Index: 1
Last. Ya-Ching HsiehH-Index: 1
view all 5 authors...
80 CitationsSource
#1Evie H. Carchman (University of Pittsburgh)H-Index: 5
#2Jayashree Rao (University of Pittsburgh)H-Index: 8
Last. Brian S. Zuckerbraun (University of Pittsburgh)H-Index: 42
view all 5 authors...
Adaptive responses to sepsis are necessary to prevent organ failure and death. Cellular signaling responses that limit cell death and structural damage allow a cell to withstand insult from sepsis to prevent irreversible organ dysfunction. One such protective pathway to reduce hepatocellular injury is the up-regulation of heme oxygenase-1 (HO-1) signaling. HO-1 is up-regulated in the liver in response to multiple stressors, including sepsis and lipopolysaccharide (LPS), and has been shown to lim...
142 CitationsSource
#1Wei-Shan ChienH-Index: 1
#2Yen-Hsu ChenH-Index: 5
Last. Chin HsuH-Index: 17
view all 7 authors...
Sepsis develops as a result of the host response to infection, and its mortality rate in ICU remains high. Severe inflammation usually causes overproductions of proinflammatory cytokines, i.e., TNF-! and reactive oxygen species, which lead to mitochondrial damage and energetic depletion. Autophagy is a survival mechanism for eukaryote to recycle intracellular nutrients and maintain energy homeostasis. We hypothesize that autophagy plays a beneficial role in the pathogenesis of organ failure duri...
33 CitationsSource
Cited By25
#1Charles L. Edelstein (Anschutz Medical Campus)H-Index: 59
#2Manjeri A. Venkatachalam (University of Texas Health Science Center at San Antonio)H-Index: 51
Last. Zheng Dong (Charlie Norwood VA Medical Center)H-Index: 54
view all 3 authors...
#1Xiao-Jing Wu (WHU: Wuhan University)H-Index: 1
#1Xiaojing Wu (WHU: Wuhan University)H-Index: 2
Last. Kai Chen (WHU: Wuhan University)H-Index: 5
view all 13 authors...
Abstract Background Previous studies showed that GTS-21, a selective alpha 7 nAchR agonist, can trigger anti-inflammatory effects and improve the survival of septic animals. However, whether GTS-21 affects autophagy responses remains unclear. Here, we tested the hypothesis that GTS-21 ameliorates sepsis-induced hepatic injury by modulating autophagy in mice. Method C57BL/6 male mice were randomly separated and categorized into four groups: the sham group, and CLP group subjected to caecal ligati...
#1Vijay Kumar (UQ: University of Queensland)H-Index: 5
#1Kumar Vijay (UQ: University of Queensland)H-Index: 1
Abstract Sepsis is a life-threatening condition originating as a result of systemic blood infection causing, one or more organ damage due to the dysregulation of the immune response. In 2017, the world health organization (WHO) declared sepsis as a disease of global health priority, needing special attention due to its high prevalence and mortality around the world. Most of the therapeutics targeting sepsis have failed in the clinics. The present review highlights the history of the sepsis, its ...
1 CitationsSource
#1Huaxin Wang (WHU: Wuhan University)
#2Xuan Peng (WHU: Wuhan University)
Last. Liying Zhan (WHU: Wuhan University)
view all 6 authors...
Purpose The aim of this study was to investigate whether propofol could attenuate hypoxia/reoxygenation-induced apoptosis and autophagy in human renal proximal tubular cells (HK-2) by inhibiting JNK activation.
#1Xi-e Xu (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Lu Liu (HUST: Huazhong University of Science and Technology)
Last. Xing-hua Liu (HUST: Huazhong University of Science and Technology)H-Index: 1
view all 9 authors...
Abstract Sepsis-associated encephalopathy (SAE) manifested clinically in acute and long-term cognitive impairments and associated with increased morbidity and mortality worldwide. The potential pathological changes of SAE are complex and remain to be elucidated. Pyroptosis, a novel programmed cell death, is executed by caspase-1-cleaved GSDMD N-terminal (GSDMD-NT) and we investigated it in peripheral blood immunocytes of septic patients previously. Here, a caspase-1 inhibitor VX765 was treated w...
#1Nicolas Tardif (KI: Karolinska Institutet)H-Index: 4
#2Franck Polia (KI: Karolinska Institutet)
Last. Olav Rooyackers (KI: Karolinska Institutet)H-Index: 33
view all 5 authors...
Recent clinical trials suggest that early nutritional support might block the induction of autophagy in critically ill patients leading to the development of organ failure. However, the regulation of autophagy, especially by nutrients, in critical illness is largely unclear. The autophagy flux (AF) in relation to critical illness and nutrition was investigated by using an in vitro model of human primary myotubes incubated with serum from critically ill patients (ICU). AF was calculated as the di...
#1Jia Jia (PRC: China Medical University (PRC))H-Index: 2
#2Xiaoying Gong (PRC: China Medical University (PRC))H-Index: 3
Last. Guofu Li (PRC: China Medical University (PRC))H-Index: 6
view all 8 authors...
Alpha-lipoic acid (ALA) reportedly has protective effects against sepsis, which is a leading cause of mortality worldwide and is associated with multiple organ dysfunction. The present study aimed to investigate further the possible action mechanisms of ALA. Male Sprague-Dawley rats were subjected to cecal ligation and puncture (CLP) in order to establish a sepsis model. The rats received an oral gavage of 200 mg/kg ALA or saline immediately after surgery. The heart rate (HR), left ventricular s...
#1Wei Cheng Mm (Peking Union Medical College Hospital)H-Index: 1
#2Yun Long (Peking Union Medical College Hospital)H-Index: 10
Last. Na Cui (Peking Union Medical College Hospital)H-Index: 6
view all 6 authors...
Abstract Background Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication of sepsis. Mammalian target of rapamycin (mTOR) signalling pathway is significantly associated with SIMD in an animal model; however, there have been no clinical studies of the association in humans. Methods We enrolled 88 patients with sepsis who were admitted to the intensive care unit (ICU) between April 2017, and April 2018. Biochemical indexes, hemodynamic parameters, and bedside echocardiogr...
1 CitationsSource
#1You Wu (First Affiliated Hospital of Wenzhou Medical University)H-Index: 1
#2Yong-Ming Yao (First Affiliated Hospital of Wenzhou Medical University)
Last. Zhongqiu Lu (First Affiliated Hospital of Wenzhou Medical University)H-Index: 20
view all 3 authors...
Sepsis is a dysregulated response to severe infection characterized by life-threatening organ failure and is the leading cause of mortality worldwide. Multiple organ failure is the central characteristic of sepsis and is associated with poor outcome of septic patients. Ultrastructural damage to the mitochondria and mitochondrial dysfunction are reported in sepsis. Mitochondrial dysfunction with subsequent ATP deficiency, excessive reactive oxygen species (ROS) release, and cytochrome c release a...
#1Yuxiao SunH-Index: 1
#2Ying CaiH-Index: 1
Last. Qun S. ZangH-Index: 1
view all 3 authors...
Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypotheses of how autophagy changes in the heart during sepsis and the underlying mechanisms. Recent investigations suggest that specific activation of autophagy initiation factor Beclin-1 has a potential to protect cardiac mitochondria, attenuate inflammation, ...
4 CitationsSource