Circadian rhythm and the phenotype of major depressive disorder

Middle East Current Psychiatry 2011, 18:29–36 Introduction For many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders, such as major depression. The objectives behind this study were to investigate whether cortisol circadian rhythm could be considered as a biomarker for major depression, to identify whether different circadian rhythm alterations in patients with major...