Regulation of T follicular helper cells by CD8+ regulatory T cells reduces pro-atherogenict tertiary lymphoid organ formation in apolipoprotein E KO mice

Tertiary lymphoid organs (TLOs), composed of B cell follicles, develop in the adventitia of atherosclerotic arteries. However, it is not known whether TLOs play an effective role in atherogenesis. In order to address this issue it is necessary to modulate the formation/function of these ectopic B cell follicles within the adventitia. Recent studies have shown that the function of germinal center B cells in secondary lymphoid organs (SLO) is...