Characterizing Variability of In Vivo Raman Spectroscopic Properties of Different Anatomical Sites of Normal Colorectal Tissue towards Cancer Diagnosis at Colonoscopy

This study aims to characterize the in vivo Raman spectroscopic properties of normal colorectal tissues and to assess distinctive biomolecular variations of different anatomical locations in the colorectum for cancer diagnosis. We have developed a novel 785 nm excitation fiber-optic Raman endoscope that can simultaneously acquire in vivo fingerprint (FP) spectra (800–1800 cm–1) and high-wavenumber (HW) Raman spectra (2800–3600 cm–1) from the...