Structure-Activity Relationship Study of TXA2 Receptor Antagonists. 4-(2-(4-Substituted Phenylsulfonylamino)ethylthio)phenoxyacetic Acids and Related Compounds.

We have recently reported that 4-[2-(4-substituted phenylsulfonylamino)ethylthio]phenoxyacetic acids and related compounds showed potent thromboxane A2 (TXA2) receptor antagonist activity. To understand how substituents affect the biological activity, the quantitative structure-activity relationship (QSAR) was analyzed by using the Hansch-Fujita method for 36 compounds, including newly synthesized compounds. The positive coefficient for πR and...